Page 10 - Fabroven Estudio Clinico

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COPYRIGHT 2017 EDIZIONI MINERVA MEDICA
KaKKoS eFFICaCy oF RUSCUS, HMC aND VItaMIN C oN VeNoUS SyMPtoMS

a

B
Figure 9.—Paresthesia was significantly reduced with the use of Ruscus compared with placebo when assessed as a continuous variable (SMD -0.86,
40 participants in one study) (a) or a categorical variable (rr=0.27, 79 participants in 2 studies) (B).

Figure 10.—A non-significant trend was observed for burning sensation with the use of Ruscus compared with placebo when assessed as a continu-
ous variable (SMD=-0.42, 60 participants in one study).

analysis, use of a placebo and a double-blind design is in clinical practice patients often refer to what they feel
of paramount importance. after swelling of their varicosities and not as a result
We demonstrated that leg symptoms specific for of ankle edema. However tingling sensation is thought
CVD, like pain, heaviness, feeling of swelling, fatigue, to be the result of peripheral neuropathy due to venous
and paresthesia were all significantly reduced in patients hypertension as previously described, 19, 20 and the large
treated with Ruscus extracts compared with placebo on effect size (rr=0.26) with Ruscus indicates a potent
quantitative analysis. Effect size varied approximately mode of action. Nevertheless, the large effect size for
between 0.25 and 0.50 for categorical variables, indi- most symptoms tested by the rCts included herein ac-
cating a large effect of Ruscus in ameliorating venous counts for the corresponding very small NNt calculated
symptoms. the symptoms of pain, heaviness, feeling of for most symptoms. the last observation strongly sup-
swelling and finally fatigue may well be intercorrelated ports the use of Ruscus extracts in patients with CVD
and the result of venous incompetence leading to hyper- and calls for formal cost-effectiveness analyses.
or other proprietary information of the Publisher. sation, which was reduced on sensitivity analysis may the current meta-analysis, as expressed by ankle cir-
Consistent findings on the effect of Ruscus extracts
tension and fluid extravasation. The finding of consid-
3
on objective measures of leg edema were observed by
erable heterogeneity for studies assessing feeling of sen-
cumference and leg or foot volume with no significant
be the effect of the variable meaning of swelling, which

april 2017
102
INterNatIoNal aNgIology