Page 4 - Fabroven Estudio Clinico

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KaKKoS eFFICaCy oF RUSCUS, HMC aND VItaMIN C oN VeNoUS SyMPtoMS

An additional six RCTs were identified through alterna- thrombotic syndrome, but only one of them provided
tive resources as described in methodology, increasing separate analyses for patients with and without post-
the number of eligible studies to 10 in total. 9-18 these thrombotic syndrome. trial duration was variable,
16
investigated a total of 719 patients. Key characteristics mostly reported to be between 4 and 12 weeks. Use of
of these trials are shown in table I. CVD CeaP clinical compression was either not allowed or not specified, ex-
class ranged between 2-5, but it was mostly 3-4; some cept two trials where it was either allowed, or used in
11
studies allowed the inclusion of patients with post- all patients. all trials except one assessed at least two
15

Table I.— Characteristics of studies included in the meta-analysis.
trial
trial N. Study population Medication and dose in active group duration Compression Symptoms assessed
allowed
elbaz (1976) 11 100 Chronic venous Cyclo 3 14 weeks yes (N.=12) Heaviness, pain, cramps,
insufficiency, 1 amp t.i.d. edema, itching
including PtS
(N.=10)
Questel (1983) 14 40 Functional extracts of Ruscus aculeatus (60 mg) 1 month Unclear Heaviness, pain, edema,
disorders related extracts of Ribes nigrum (550 mg), paresthesia
to venous and ascorbic acid (200 mg)
insufficiency, 3 tb b.i.d.
including PtS
(N.=7)
le Devehat (1984) 12 35 Venous Cyclo 3 6 weeks Unclear Heaviness, edema
insufficiency 3 ml/day Ruscus extract, equivalent
to 6 amp/day
Braun (1985) 10 50 Venous edema Phlebodril (75 mg Ruscus extract, 4 weeks Unclear Fatigue, tension and
75 mg trimethyl hesperidin heaviness in the legs,
chalcone, 50 mg ascorbic acid) evening swelling of the
1 cap b.i.d. lower leg or foot
In addition, cream containing Ruscus
extract applied in the evening
Sentou (1985) 17 37 Mild to moderate Cyclo 3 4 weeks Unclear Heaviness and tension,
chronic venous 2 caps t.i.d. cramps, edema, paresthesia
insufficiency,
including PtS
altenkamp (1987) 9 50 Chronic venous Phlebodril 4 weeks Unclear tiredness, tension and
insufficiency, 2 caps t.i.d. heaviness in the legs, pain,
stages I and II evening swelling of the
lower leg or foot
rieger (1988) 15 40 Chronic venous Phlebodril 15 days Intermittent Pain, sensation of fatigue,
insufficiency, PTS 2 caps t.i.d. compression swelling and tension in the
allowed (Jobst legs, and evening swelling
technique) and of the lower leg or foot
compressive
bandaging
rudofsky (1990) 16 141 Mild chronic Phlebodril 12 weeks Unclear None, only objective
venous 2 caps t.i.d. for 4 weeks, then 2 caps assessment of edema and
insufficiency, b.i.d. other venous hemodynamic
including PtS parameters.
Parrado (1999) 13 60 Chronic venous Cyclo 3 Fort (150 mg Ruscus extract, 2 months No Heaviness, pain, cramps,
insufficiency, 150 mg trimethyl hesperidin burning sensation, pruritus,
stages I and II chalcone, 150 mg ascorbic acid) tiredness and sensation of
1 cap b.i.d. evening swelling in the
lower limbs
or other proprietary information of the Publisher. PtS: post-thrombotic syndrome. INterNatIoNal aNgIology april 2017
tiredness, heaviness,
No
Fagorutin (36.0-37.5 mg dry extract
166 Chronic venous
12 weeks
Vanscheidt (2002) 18
sensation of tension,
from butcher’s broom rhizome)
disease CeaP
clinical class 3-5
paresthesia, pain
1 cap b.i.d.
total
719
96